Exploring GLP-1: What It Is, How You Make It & Ways to Support It Naturally (Including Supplements That Can Help!)

GLP-1, or glucagon-like peptide-1, plays a key role in regulating blood sugar, appetite, and weight. Understanding how GLP-1 works in the body and learning natural ways to support its production can help improve insulin use, reduce inflammation, and support healthy weight management. This post explains what GLP-1 is, how the body produces it, and practical ways to boost it naturally. We also highlight specific supplements that are clinically researched and designed to help.

What Is GLP-1 and How Does It Work?

GLP-1 isn't a medicine, it's a hormone produced in the gut after eating. It helps the body manage blood sugar by stimulating insulin release and slowing down digestion. This hormone also signals the brain to reduce appetite, which can support weight control.

When you eat, GLP-1 is released from intestinal cells and travels through the bloodstream to the pancreas and brain. In the pancreas, it encourages insulin secretion, helping cells absorb glucose and lower blood sugar levels. In the brain, it promotes feelings of fullness, reducing food intake.

GLP-1 also reduces inflammation and improves how the body uses insulin, which is important for preventing insulin resistance and type 2 diabetes.

How the Body Naturally Produces GLP-1

The body produces GLP-1 mainly in the intestines, especially in response to food intake. Certain nutrients and dietary fibers stimulate the release of GLP-1. For example:

• Dietary fiber slows digestion and promotes GLP-1 secretion.

• Protein-rich foods can increase GLP-1 levels.

• Healthy fats also support GLP-1 release.

  
  

Gut health plays a role too. A balanced gut microbiome helps maintain GLP-1 production, while inflammation or poor gut health can reduce it.

Natural Ways to Boost GLP-1

If you are looking to increase GLP-1 production naturally, that involves diet modifications, exercise/lifestyle changes, and potentially adding supplements. Here are some effective strategies:

1. Eat More Fiber

Fiber-rich foods like vegetables, fruits, legumes, and whole grains slow digestion and stimulate GLP-1 release. Fiber also feeds beneficial gut bacteria, which further supports GLP-1 production.

2. Include Protein and Healthy Fats

Meals with balanced protein and healthy fats promote steady GLP-1 release. Examples include lean meats, fish, nuts, seeds, and olive oil.

3. Exercise Regularly

Physical activity improves insulin sensitivity and may increase GLP-1 levels. Aim for a mix of aerobic and strength training exercises.

4. Manage Stress and Sleep

Chronic stress and poor sleep can disrupt hormone balance, including GLP-1. Prioritize restful sleep and stress reduction techniques like meditation or yoga.

Supplements That Support GLP-1 and Metabolic Health

Certain supplements can help boost GLP-1 naturally, improve blood sugar regulation, reduce inflammation, and curb appetite. Orthomolecular offers several products designed to support these goals.

Fiber

Did you know only 5% of the population gets enough fiber in their daily diet? One of our favorite fiber products is Orthmolecular's Fiber MPG. This product provides 11 grams of varied, clinically researched fibers that promote a healthy microbiome foundation, improve satiety and glycemic control via GLP-1 and PYY stimulation, and support prebiotic seeding. This unique formula promotes regularity, gut biome balance and metabolic wellness.

Inositol

Orthomolecular's InosiCare is a unique formula designed to support metabolic, hormonal and gut health through a combination of researched and targeted ingredients. By focusing on key pathways involved in energy metabolism, blood sugar regulation and hormonal balance, it provides a comprehensive solution for individuals seeking natural support for metabolic efficiency and overall wellbeing. At the heart of InsoiCare is a blend of myo- and D--chiro inositol in a 40:1 ration; this is a clinically researched combination shown to improve insulin sensitivity, promote regular ovulation, and support healthy hormone balance. It's ideal for people struggling with PCOS.

Amarasate

Orthomolecular's CaloCurb is a new product designed to curb appetite and support weight loss by influencing GLP-1, CCK and PYY pathways. It contains Amarasate, derived from bitter hops, which has been shown in some studies to increase GLP-1 production by 600%, reduce calories by 18%, reduce hunger by 30% and reduce cravings by 40%.

Berberine

Berberine is a plant compound known for its ability to improve insulin sensitivity and reduce inflammation. Research shows it can increase GLP-1 secretion, helping regulate blood sugar and support weight loss. It works well alongside fiber and inositol supplements and is a great choice for individuals seeking to support metabolic, cardiovascular and GI healthy. Studies show it can also support metabolism of fat in the liver and have positive benefits for a healthier body composition. It is also a good choice for those with PCOS issues.

Other Natural Compounds That Help Boost GLP-1

Besides Orthomolecular products and berberine, several other natural substances support GLP-1 and metabolic health:

• Resveratrol found in grapes and berries may enhance GLP-1 secretion.

• Curcumin from turmeric reduces inflammation and supports insulin function.

• Magnesium helps improve insulin sensitivity and may influence GLP-1 levels.

• Probiotics improve gut health and can indirectly boost GLP-1 production.

  
  

Practical Tips to Support GLP-1 Every Day

• Start meals with fiber-rich vegetables or a small salad.

• Include a source of protein and healthy fat at every meal.

• Consider adding targeted supplements to your routine.

• Use CaloCurb if you struggle with appetite control.

• Add berberine after consulting with a healthcare provider due to possible med interactions.

• Stay active and manage stress to support hormone balance.

If weight loss has ever felt harder than it “should,” you’re not imagining it. Hormonal imbalances, metabolic changes, and conditions like diabetes and PCOS can significantly affect how your body responds to diet and exercise — and willpower alone is rarely the answer.

That’s where informed guidance matters. We focus on high-quality, well-researched, third-party tested supplements and personalized recommendations designed to work with your body, not against it. If you’re feeling stuck or overwhelmed, we’re here to help you take the next step with clarity and confidence. Stop in and review our selection of these products or call us today at 651-232-6830 to learn how we may be able to help you formulate a tailored plan!